The experiences of postgraduate psychology students regarding the development of multicultural competence

This study investigated the experiences of postgraduate psychology students regarding their multicultural competence development (MCCD). King and Baxter Magolda’s multidimensional framework for the development of intercultural maturity, comprising cognitive, interpersonal and intrapersonal dimensions served as theoretical grounding. A qualitative, case study design was employed, using thematic analysis to analyse focus group data. It was found MCCD takes place across the lifespan and in various contexts. Methods to overcome obstacles to MCCD were identified, as well as the participants’ positions of MCCD. Lastly, educational experiences that promote MCCD are discussed

Economic and Epidemiological Effects of Mandated and Spontaneous Social Distancing

Based on a standard epidemiological model, we derive and apply empirical tests of the hypothesis that contacts, as proxied by mobility data, have an effect on the spread of the coronavirus epidemic, as summarized by the reproduction rates, and on economic activity, as captured by subsequent initial claims to unemployment benefits. We show that changes in mobility through the first quarters of 2020, be it spontaneous or mandated, had significant effects on both the spread of the coronavirus and the economy. Strikingly, we find that spontaneous social distancing was no less costly than mandated social distancing. Our results suggest that the rebound in economic activity when stay-at-home orders were lifted was primarily driven by the improvement in epidemiological parameters. In other words, without the reduction in the reproduction rate of the coronavirus, we could have expected a doubling down on spontaneous social distancing

The Elusive Gains from Nationally-Oriented Monetary Policy

The consensus in the recent literature is that the gains from international monetary cooperation are negligible, and so are the costs of a breakdown in cooperation. However, when assessed conditionally on empirically-relevant dynamic developments of the economy, the welfare cost of moving away from regimes of explicit or implicit cooperation may rise to multiple times the cost of economic fluctuations. In economies with incomplete markets, the incentives to act non-cooperatively are driven by the emergence of global imbalances, i.e., large net-foreign-asset positions; and, in economies with complete markets, by divergent real wages

Precise Charm- and Bottom-Quark Masses: Theoretical and Experimental Uncertainties

Recent theoretical and experimental improvements in the determination of charm and bottom quark masses are discussed. A new and improved evaluation of the contribution from the gluon condensate $$ to the charm mass determination and a detailed study of potential uncertainties in the continuum cross section for $b\bar b$ production is presented, together with a study of the parametric uncertainty from the $\alpha_s$-dependence of our results. The final results, $m_c(3 \text{GeV})=986(13)$MeV and $m_b(m_b)=4163(16)$MeV, represent, together with a closely related lattice determination $m_c(3\;{\rm GeV})=986(6)$MeV, the presently most precise determinations of these two fundamental Standard Model parameters. A critical analysis of the theoretical and experimental uncertainties is presented.Comment: 12 pages, presented at Quarks~2010, 16th International Seminar of High Energy Physics, Kolomna, Russia, June 6-12, 2010; v2: references adde

Widespread detection of highly pathogenic H5 influenza viruses in wild birds from the Pacific Flyway of the United States

A novel highly pathogenic avian influenza virus belonging to the H5 clade 2.3.4.4 variant viruses was detected in North America in late 2014. Motivated by the identification of these viruses in domestic poultry in Canada, an intensive study was initiated to conduct highly pathogenic avian influenza surveillance in wild birds in the Pacific Flyway of the United States. A total of 4,729 hunter-harvested wild birds were sampled and highly pathogenic avian influenza virus was detected in 1.3% (n = 63). Three H5 clade 2.3.4.4 subtypes were isolated from wild birds, H5N2, H5N8, and H5N1, representing the wholly Eurasian lineage H5N8 and two novel reassortant viruses. Testing of 150 additional wild birds during avian morbidity and mortality investigations in Washington yielded 10 (6.7%) additional highly pathogenic avian influenza isolates (H5N8 = 3 and H5N2 = 7). The geographically widespread detection of these viruses in apparently healthy wild waterfowl suggest that the H5 clade 2.3.4.4 variant viruses may behave similarly in this taxonomic group whereby many waterfowl species are susceptible to infection but do not demonstrate obvious clinical disease. Despite these findings in wild waterfowl, mortality has been documented for some wild bird species and losses in US domestic poultry during the first half of 2015 were unprecedented

LYL1 Degradation by the Proteasome Is Directed by a N-Terminal PEST Rich Site in a Phosphorylation-Independent Manner

Background: The Lymphoblastic leukemia 1 (LYL1) gene is a proto-oncogenic transcription factor found upregulated in patients with T-cell acute lymphoblastic leukemia (T-cell ALL). Initially, the upregulation was described to be as a result of a translocation. However, further studies revealed that transcriptional upregulation of LYL1could also occur without translocations. In addition, post-translational mechanisms, such as protein degradation could influence LYL1 expression as well. Methodology/Principal Findings: In this study, we considered possible post-translational regulation of Lyl1, and investigated fundamental mechanisms governing LYL1 degradation in cell-based culture assays. We identify a PEST sequence motif located in the N-terminus of LYL1, which determines the efficiency of LYL1 degradation by the proteasome. The absence of the PEST degradation site leads to accumulation or upregulation of LYL1. We also show that LYL1 is phosphorylated by MAPK at S36, and determined that proteasomal degradation of LYL1 occurs in a phosphorylationindependent manner. Conclusions/Significance: Understanding LYL1 degradation is a step forward not only towards deciphering the normal function and regulation of LYL1, but could suggest post-translational mechanisms for upregulation of LYL1 that ma

Drosophila Nociceptors Mediate Larval Aversion to Dry Surface Environments Utilizing Both the Painless TRP Channel and the DEG/ENaC Subunit, PPK1

A subset of sensory neurons embedded within the Drosophila larval body wall have been characterized as high-threshold polymodal nociceptors capable of responding to noxious heat and noxious mechanical stimulation. They are also sensitized by UV-induced tissue damage leading to both thermal hyperalgesia and allodynia very similar to that observed in vertebrate nociceptors. We show that the class IV multiple-dendritic(mdIV) nociceptors are also required for a normal larval aversion to locomotion on to a dry surface environment. Drosophila melanogaster larvae are acutely susceptible to desiccation displaying a strong aversion to locomotion on dry surfaces severely limiting the distance of movement away from a moist food source. Transgenic inactivation of mdIV nociceptor neurons resulted in larvae moving inappropriately into regions of low humidity at the top of the vial reflected as an increased overall pupation height and larval desiccation. This larval lethal desiccation phenotype was not observed in wild-type controls and was completely suppressed by growth in conditions of high humidity. Transgenic hyperactivation of mdIV nociceptors caused a reciprocal hypersensitivity to dry surfaces resulting in drastically decreased pupation height but did not induce the writhing nocifensive response previously associated with mdIV nociceptor activation by noxious heat or harsh mechanical stimuli. Larvae carrying mutations in either the Drosophila TRP channel, Painless, or the degenerin/epithelial sodium channel subunit Pickpocket1(PPK1), both expressed in mdIV nociceptors, showed the same inappropriate increased pupation height and lethal desiccation observed with mdIV nociceptor inactivation. Larval aversion to dry surfaces appears to utilize the same or overlapping sensory transduction pathways activated by noxious heat and harsh mechanical stimulation but with strikingly different sensitivities and disparate physiological responses